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Immunology: Why the Thymus Culls Most of Its Recruits

How your body tells friend from foe, from the first-line defenses you were born with to antibodies, memory, vaccines, allergies and autoimmunity.

Immunology · 50 questions

Try 3 questions

1. During an infection, what actually causes a fever?

  1. Bacteria give off heat as they multiply
  2. Immune signals reset the brain's thermostat
  3. Muscles overheat from fighting the germs
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Answer: Immune signals reset the brain's thermostat

Cytokines such as interleukin-1 prompt the hypothalamus to raise its temperature set point; the body then conserves and generates heat, which is why you shiver.

2. Pus is mostly made of what?

  1. Lymph fluid leaking from vessels
  2. Dead neutrophils and tissue debris
  3. Dead bacteria and nothing else
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Answer: Dead neutrophils and tissue debris

Neutrophils rush to infection sites in huge numbers, engulf microbes and die within hours; their remains, with debris and fluid, form pus.

3. How do innate immune cells recognize microbes they have never encountered before?

  1. They detect molecular patterns many share
  2. They carry ready-made antibodies for each
  3. They remember them from past infections
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Answer: They detect molecular patterns many share

Receptors such as Toll-like receptors recognize structures common to whole groups of microbes, like bacterial cell-wall components or viral RNA, without any prior exposure.

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