Pharmacology quizzes
How medicines work in the body, what they treat, and why they can cause side effects or interact.
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A weakly basic drug sitting in the acidic stomach will be mostly in which state?
- Un-ionized, so rapidly absorbed there
- Ionized, so poorly absorbed there
- Split evenly between both forms
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Answer: Ionized, so poorly absorbed there
Bases pick up protons in acid and become charged; charged molecules cross membranes poorly, so weak bases are absorbed mainly after reaching the more alkaline intestine.
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